Serenity CALM Welltrients™

Ingredient Summary

L-Arginine Arginine is an essential amino acid to children, and relatively essential to adults. Arginine is secreted by the anterior pituitary glands and aids in the stimulation and release of Human Growth Hormone (HGH) from the pituitary. Arginine is rapidly interconverted with ornithine.

L-Glycine Glycine is a non essential amino acid utilized by the liver in the synthesis of other nonessential amino acids and part of the tripeptide glutathione. L-Glycine has natural calming properties as a major inhibitory neurotransmitter of the brain, readily and easily passing the brain-blood barrier, working in conjunction with GABA and Taurine as a anticonvulsant.

L-Lysine L-Lysine an essential amino acid as a necessary building block for all protein in the body, carries a positive charge and facilitate the absorption of calcium from the small intestine. Lysine strengthens the thymus which subsequently improves immune system parameters and is important in the body's production of hormones, enzymes, and antibodies.

L-Tyrosine Tyrosine is a conditionally essential amino acid which works in the presence of Ascorbate (vitamin C). Tyrosine is a nutritional co-precursor of thyroid hormones and some neurochemicals called catecholamines which are natural hormonal substances that act as extra cellular messengers between the brain, central nervous tissue and endocrine system. Tyrosine is indirectly is a nutritional precursor to dopa, dopamine, norepinephrine (noradrenaline) and epinephrine (adrenaline). Tyrosine is a necessary constituent of normal brain function. Tyrosine passes through the brain-blood barrier, reacting positively with the BCAA's (branched chain amino acids). Tyrosine is primarily concentrated in brain tubulin, an intracellular protein, important for the formation, structure and integrity of neurons and neural pathways.

L-Glutamine L-Glutamine as an inhibitory neurotransmitter is taken up by glial cells (or glia) which are the supporting, non-neuronal cells of the central nervous system (CNS). They are as important as the neurons, which could not function without them. They wrap around and enclose the axons, dendrites, synapses and blood vessels. They probably control the composition of the interstitial medium. There are about ten times more glial cells than neurons in the CNS. After Glutamic acid uptake via the glial cells, Glutamine is quickly converted to Glutamic acid, and then diffused into the neurons, resupplying glutamine deficiencies. Glutamic acid as an excitatory neurotransmitter, balancing the possibility of inhibitory overload (shutting down the inhibitory systems of GABA) so that the smooth muscles of vascular groups do not become too relaxed.

L-Ornithine Ornithine is an nonessential amino acid, not coded for by DNA and is not involved in protein synthesis, that can be rapidly interconverted with arginine. Ornithine is one of the products of the action of the enzyme arginase on L-arginine, creating urea (urea cycle), which allows for the disposal of excess nitrogen. The non-hepatic body tissues use of the urea cycle is in arginine biosynthesis as an intermediate in metabolic processes.

GABA (Gamma-AminoButyric Acid) GABA is known to be an active a1- & a2-adrenergic antagonist, helping the body to relax the smooth muscle of arteries and veins. It acts via the GABA-A and GABA-B cell receptors to prevent neuronal depolarization and firing of an action potential occurring in muscles, stopping the muscle from contracting. An action potential is a rapid, transient, self-propagating electrical excitation of the membrane of electrically excitable cells, known as a spike or nerve impulse (in neurons). Action potentials occur in nerve, muscle, and neuroendocrine cells and are generated and propagated through the actions of voltage-gated ion channels. An action potential is essentially a brief (approx. 1 ms long), regenerative change in the membrane potential which occurs in electrically excitable cells such as the smooth muscle in veins and arteries. Action potentials are digital signals which encode information as a temporal sequence. With GABA, G-protein ompete for receptor binding sites (the largest family of cell-surface receptors) cin smooth muscle, ensuring that smooth muscle of arteries and veins relaxes, and that action potentials do not fire. As the smooth muscle relaxes, arteries and veins begin to vasodilate, increasing their circumference, allowing more blood to flow which subsequently reduces blood pressure throughout the circulatory system. GABA, a quasi-amino acid, may be one of the most powerful inhibitory neurotransmitters in the central nervous system operating as a chemical messenger to its neighbors. GABA is important in helping the body to naturally regulate nerve function and enhance the ability of vitamin B3 (niacin) to act. GABA, one of the three musketeers (GABA, Glutamine [GAM] and Glutamic acid [GA]), is believed to be capable of providing needed nutrition and energy for the brain. GABA has been found to be deficient in clinical and experimental seizure disorders and is the most widely distributed inhibitory neurotransmitter in the brain. GABA is helpful in bringing calmness to the body, promoting tranquility and peace in times of stress and anxiety.

L-Threonine Threonine is an essential amino acid and is a precursor of the amino acids glycine and serine.

5-HTP (5-hydroxytryptophan) 5-Hydroxytryptophan or 5-HTP is a naturally-occurring amino acid, a precursor to the neurotransmitter serotonin and an intermediate in tryptophan metabolism. and is decarboxylated to serotonin with the help of pyridoxal 5 phosphate.

Vitamin B1 (Thiamine) An essential vitamin necessary for proper metabolism of sugar and starch to provide energy in the body. Thiamine also functions in the nerves, brain and heart, digestive and the whole nervous system, and is important for the maintenance of healthy, clear, luminous eyes, hair and skin. Thiamine has a vital neurological function in the nervous system independent of its coenzyme role. An active form of thiamine in the body is thiamine pyrophosphate (AKA thiamine diphosphate or cocarboxylase). Stimulation of nerves results in the release of thiamine monophosphate and free thiamine into the associated medium with accompanying decrease of cellular thiamine pyrophosphate and thiamine triphosphate. The concentration of thiamine in the brain seems to be resistant to changes dietary concentration. In the brain the concentration of thiamine is quick to release, but slow to replemish. Thiamine triphosphate (another internal form) is involved with nerve impulses via the Na+ and K+ gradient.

Vitamin C (Ascorbate) Vitamin C as an ascorbate is an essential nutrient required for metabolic reactions. Vitamin C is an effective antioxidant, an ascorbate peroxidase substrate, an enzyme cofactor for the biosynthesis of many biochemicals and an electron donor for enzymes. The active form of vitamin C is the ascorbate ion, a strong reducing agent that gets converted to its oxidized form, L-dehydroascorbate in the body by enzymes and glutathione. It is a weak sugar acid structurally related to glucose, which naturally occurs either attached to a hydrogen ion (ascorbic acid), or to a mineral ion (a mineral ascorbate). The biological halflife for vitamin C is about 30 minutes in blood plasma.

Vitamin B3 (Niacin, Inositol hexinicotinate) Niacin is a water-soluble vitamin, whose derivatives play essential roles in energy metabolism in the cell and DNA repair. Niacin is a critical essential coenzyme for anti-stress, helping the body in general healing. Niacin assists in the functioning of the nervous system; in the metabolism of carbohydrates, fats, and proteins; and in the production of hydrochloric acid for the digestive system.

Vitamin B6 (Pyridoxal 5 phosphate) The bioactive metabolite of Vitamin B-6, Pyridoxil 5'-phosphate is a coenzyme of many enzymatic reactions. It is the active form of Vitamin B-6 which comprises three natural organic compounds, pyridoxal, pyridoxamine and pyridoxine. Pyridoxil 5'-phosphate acts as a coenzyme in all transamination reactions, and in some decarboxylation and deamination reactions of amino acids.