Nite MGR™

Vitamin C (Ascorbate)   Vitamin C as an ascorbate is an essential nutrient required for metabolic reactions. Vitamin C is an effective antioxidant, an ascorbate peroxidase substrate, an enzyme cofactor for the biosynthesis of many biochemicals and an electron donor for enzymes.   The active form of vitamin C is the ascorbate ion, a strong reducing agent that gets converted to its oxidized form, L-dehydroascorbate in the body by enzymes and glutathione. It is a weak sugar acid structurally related to glucose, which naturally occurs either attached to a hydrogen ion (ascorbic acid), or to a mineral ion (a mineral ascorbate). The biological halflife for vitamin C is about 30 minutes in blood plasma.

Vitamin D3 (Cholecalciferol)   A fat-soluble vitamin essential to one's health. Regulates the amount of calcium and phosphorus in the blood by improving their absorption and utilization. Necessary for normal growth and formation of bones and teeth.   Vitamin D3 signals the pituitary gland to release growth hormones, and controls the release of melatonin.

Vitamin B3 (Niacin, Inositol hexinicotinate)   Niacin is a critical essential coenzyme for anti-stress, helping the body in general healing. Niacin assists in the functioning of the nervous system; in the metabolism of carbohydrates, fats, and proteins; and in the production of hydrochloric acid for the digestive system.

Vitamin B6 (Pyridoxal 5 phosphate)   Vitamin B-6 is comprised of three natural organic compounds; pyridoxal (Pyridoxal 5 phosphate), pyridoxamine and pyridoxine. Pyridoxal 5 phosphate is the bioactive metabolite of the coenzyme Vitamin B-6 involved in many important enzymatic reactions.   Pyridoxil 5'-phosphate acts as a coenzyme in all transamination reactions, and in some decarboxylation and deamination reactions of amino acids.

Inositol (Inositol, Inositol hexinicotinate)   Inositol's primary function is in cell membrane structure and integrity. Along with choline, it may help in brain cell nutrition.   Inositol is a key intermediate molecule of second messenger signal transduction pathways used by serotonergic, cholinergic, and noradrenergic neurons. Inositol is involved in signal transduction pathways involving the neurotransmitter serotonin.

Calcium (Ascorbate)   Calcium (Ca) is an essential alkaline nutrient element required by every cell in the body and is the most abundent mineral in the body.   A calcium deficiency in the body causes restlessness and wakefulness.   Calcium helps the brain use the tryptophan to manufacture melatonin.

Magnesium (Glycinate Chelate)   Magnesium “Magnesium glycinate” is a, better tolerated and more absorbable, chelated form of the mineral magnesium (Mg). The element magnesium is an essential mineral involved in over 350 biochemical actions in the body.   Magnesium relaxes smooth muscle, helps dilate blood vessels and maintains blood flow.

L-Ornithine   Ornithine is an nonessential amino acid, not coded for by DNA and is not involved in protein synthesis, that can be rapidly interconverted with arginine.

GABA (Gamma-AminoButyric Acid)   GABA (g-aminobutyric acid), one of the major inhibitory Amino Acid neurotransmitters of the central nervous system. This amino acid can be derived from another amino acid, glutamic acid.   GABA is known to be an active a1- & a2-adrenergic antagonist, helping the body to relax the smooth muscle of arteries and veins. It acts via the GABA-A and GABA-B cell receptors to prevent neuronal depolarization and firing of an action potential occurring in muscles, stopping the muscle from contracting. An action potential is a rapid, transient, self-propagating electrical excitation of the membrane of electrically excitable cells, known as a spike or nerve impulse (in neurons). Action potentials occur in nerve, muscle, and neuroendocrine cells and are generated and propagated through the actions of voltage-gated ion channels. An action potential is essentially a brief (approx. 1 ms long), regenerative change in the membrane potential which occurs in electrically excitable cells such as the smooth muscle in veins and arteries. Action potentials are digital signals which encode information as a temporal sequence. With GABA, G-protein ompete for receptor binding sites (the largest family of cell-surface receptors) cin smooth muscle, ensuring that smooth muscle of arteries and veins relaxes, and that action potentials do not fire. As the smooth muscle relaxes, arteries and veins begin to vasodilate, increasing their circumference, allowing more blood to flow which subsequently reduces blood pressure throughout the circulatory system. GABA, a quasi-amino acid, may be one of the most powerful inhibitory neurotransmitters in the central nervous system operating as a chemical messenger to its neighbors. GABA is important in helping the body to naturally regulate nerve function and enhance the ability of vitamin B3 (niacin) to act. GABA, one of the three musketeers (GABA, Glutamine [GAM] and Glutamic acid [GA]), is believed to be capable of providing needed nutrition and energy for the brain. GABA has been found to be deficient in clinical and experimental seizure disorders and is the most widely distributed inhibitory neurotransmitter in the brain. GABA is helpful in bringing calmness to the body, promoting tranquility and peace in times of stress and anxiety.

L-Glycine   Glycine is a non essential amino acid utilized by the liver in the synthesis of other nonessential amino acids and part of the tripeptide glutathione.   Glycine is a necessary constituent of collagen.   L-Glycine has natural calming properties as a major inhibitory neurotransmitter of the brain, readily and easily passing the brain-blood barrier, working in conjunction with GABA and Taurine as a anticonvulsant.   Studies found that L-Glycine increased HGH in the serum, glycine is one of the stimulatory agents inducing the pituitary glands to secrete HGH.

L-Tyrosine   L-Tyrosine is an amino acid that plays a part in the production of thyroid hormones as well as for neurotransmitters, such as dopamine, epinephrine and norepinephrine. Tyrosine requires pyridoxal 5 phosphate (P5P) to be converted to norepinephrine.   Tyrosine is a conditionally essential amino acid which works in the presence of Ascorbate (vitamin C). Tyrosine is a nutritional co-precursor of thyroid hormones and some neurochemicals called catecholamines, which are natural hormonal substances that act as extra cellular messengers between the brain, central nervous tissue and endocrine system. Tyrosine is a necessary constituent of normal brain function. Tyrosine passes through the brain-blood barrier, reacting positively with the BCAA's (branched chain amino acids).

L-Glutamine   L-Glutamine as an inhibitory neurotransmitter is taken up by glial cells (or glia) which are the supporting, non-neuronal cells of the central nervous system (CNS).   L-glutamine can penetrate the blood-brain barrier and is readily transformed into Glutamic Acid, which is essential for cerebral function (an amino acid brain fuel).   L-Glutamine stimulates GH release, fuels the immune system, helps DNA synthesis and increases cell volume, and cell division.

L-Threonine   Threonine helps maintain proper protein balance in the body while playing a key role in liver, immune and central nervous system functions. The amino acid Threonine is required to properly metabolize fats in the liver. In the nervous system, Threonine increases glycine levels important in individuals with muscle twitching and the symptoms of ALS (Amyotrophic Lateral Sclerosis). Threonine is an essential amino acid and is a precursor of the amino acids glycine and serine.

L-Theanine   L-theanine is involved in forming GABA, and has anti-stress effects by blocking glutamate receptors in the brain, reducing stress responses.   L-theanine, an amino acid is known to enhance the production of alpha brain waves, , the brain wave cycle that occurs during periods of relaxation, sleep initiation, and waking and is indicative of a calm and relaxed mind.

L-Arginine   Arginine is an essential amino acid to children, and relatively essential to adults.   Arginine is secreted by the anterior pituitary glands and aids in the stimulation and release of Human Growth Hormone (HGH) from the pituitary. Arginine is rapidly interconverted with ornithine.

L-Lysine   L-Lysine an essential amino acid as a necessary building block for all protein in the body, carries a positive charge and facilitate the absorption of calcium from the small intestine. Lysine strengthens the thymus which subsequently improves immune system parameters and is important in the body's production of hormones, enzymes, and antibodies.

Hops (Humulus lupulus)   Hops are the female flower cones of the hop plant (Humulus lupulus).   The active components isolated from the flowers of the Hops plant include Flavonoids, Chalcones and Alpha Acids, each of which are thought to promote relaxation of the CNS, reduce occasional sleep disturbances and support a positive mood balance.

Valerian Root extract (Valeriana officinalis)   Known for its effect on anxiety and nervousness-related sleeplessness, Valerian Root acts to promote smooth muscle relaxation by increasing concentrations of the neurotransmitter gamma-aminobutyric acid (GABA) in the nerve endings, resulting in a relaxing effect.

Passion Flower (Flower extract)   Historically used to promote sleep, relax muscle, and relieve digestive and uterine spasms.   The neuromuscular relaxing action of Nervous symptoms and cramps, that inhibit sleep are alleviated can lead to a restful uninterrupted and deep sleep.

Skullcap Extract (Scutellaria lateriflora)   Scutellaria Laterifolia (Skullcap) is used for nourishing the nervous system.   Skullcap quiets nervous tension and eases muscle tension and spasms, induces sleep without strongly sedating or stupefying and may help to lower elevated blood pressure.

Wild Lettuce (Lactuca)   Has been used historically to promote early sleep cycle support. Contains flavonoids, which have strong anti-oxidant properties can also contain coumarins, and N-methyl-β-phenethylamine. Two biochemical constitutes that have mild sedative and cough suppressant properties have be found in the wild Lactuca species are Lactucopicrin and Lactucin.

5-HTP (5-hydroxytryptophan)   5-Hydroxytryptophan or 5-HTP is a naturally-occurring amino acid, a precursor to the neurotransmitter serotonin and an intermediate in tryptophan metabolism. and is decarboxylated to serotonin. Tryptophan requires pyridoxal 5 phosphate (P5P) to be converted to serotonin.

Melatonin   Melatonin functions as an antioxidant and helping to regulate circadian rhythms (the body's biological clock which regulates the sleep-wake cycles). Melatonin helps to promote healthy sleep patterns. Melatonin protects cells from free radical damage, and directs the release of both growth and sex hormones.