A combination of aminos, herbal plant products and minerals to help balance sugar metabolism. All the ingredients in the Glycemic MGR™ formulation are processed to produce optimal health benefits.
The micro-nutritients in the Glycemic MGR™ include the best known, that may aid and support the body to rebuild and heal pancreatic tissues, ß-cell formations, control and manage insulin.
Suggested Use: As an Adult dietary supplement take 1 to 2 Capsules three times per day between meals daily. Early in the morning mid-morning, mid-afternoon and evening. Or as directed by your Health Care Practitioner.
Advance Use: Take up to triple the above amounts described as directed by your Health Care Practitioner.
Ingredient Summary:
Every diabetic should take these nutrients in addition to the appropriate welltrient strategy: Chromium, Vanadium,
Cinnamon,
Banaba Leaf, Fenugreek, Gymnema Sylvestre and Momordica
Momordica
Bitter melon is the common name for Momordica charantia, also known as
African cucumber, balsam pear and bitter gourd. The plant is aptly
named, as all parts of the plant, including the fruit, taste bitter.
Sold often in Asian groceries as a vegetable, bitter melon is employed
as a folk remedy primarily for regulating blood sugar in cases of
diabetes, as well as for colitis and dysentery, intestinal worms,
jaundice and fevers. The phytochemicals present in
bitter melon suggest that there are multiple uses for this herb.
Among the constituents in bitter melon, charantin is identified as an
important agent for blood-sugar regulation. Charantin demonstrates
hypoglycaemic (blood sugar lowering) or other actions of potential
benefit in diabetes. The Momordica fruit contain insulin-like peptides,
including one known as polypeptide P, and alkaloids. It is likely that
several substances in bitter melon contribute to its blood
sugar-modifying effects. In human studies, bitter melon demonstrates
significant blood-sugar control after food intake and overall blood
sugar-lowering effects.
In a study published in the journal Chemistry & Biology- March
2008, a research team, headed by Dr. Mon-Jia Tan of the Chinese Academy
of Sciences in Shanghai, concluded that bitter melon has potent
anti-diabetes effects. In their study, Tan and colleagues isolated and
described several compounds from bitter melon known as cucurbitane
triterpenoids, and tested their effects on glucose (sugar) and fat
metabolism in cells and in mice. When tested in muscle and fat cells,
the researchers found, the compounds stimulated the glucose receptor
GLUT4 to move from the cell interior to the cell surface, thus
promoting more effective glucose metabolism. Several of the tested
compounds had effects comparable to those of insulin. Tests in mice of
two of the compounds found that they promoted both glucose tolerance
and fat burning, and one was particularly effective in promoting
glucose tolerance in animals consuming high fat diets.
The researchers note that there may be as many as 70 active compounds
in bitter melon. "The present study provides an important basis for
further analysis of structure-activity relationship to develop
optimized leads from (bitter melon) for the treatment of insulin
resistance and obesity," they conclude.
Momordica has been found to be just as effective as glibenclamide
in reducing blood sugar levels (J Ethnopharmacol 2003; 88(1): 107-111).
In fact, a large study at Harvard University Medical School concluded
that mormodica is one of the best natural remedies for diabetes
(Diabetes Care 2003; 26(4): 1277-1294). It appears that mormodica
contains compounds similar in structure to insulin, which have the same
effects in regulating blood sugar levels. There is evidence that
mormodica can prevent the release of excess glucose into the
bloodstream from the liver (Am J Health Syst Pharm 2003; 60(4):
356-359).
Chromium and Vanadium are two very important minerals for diabetics.
Chromium helps insulin transport sugar to the cells. Chromium works to
make insulin more effective by "bridging" insulin to cell membranes,
thus increasing the number of active insulin receptors, resulting in
increased insulin sensitivity.
The trace mineral chromium is found in skin, fat, muscle, brain and the adrenal glands. There is about 6 mg in each of us and it is important!
Chromium absorption through the small intestine is very
poor; so normally, a lot of it gets excreted in urine. People with
diabetes excrete even more chromium than healthy people; and the loss
of this vital nutrient makes it harder for their bodies to respond to
insulin. Studies show that chromium supplements can help both Type I
and Type II diabetics control their blood sugar.
There are various forms of chromium suitable for human
ingestion. The Polynicotinate form of chromium called "Chromium polynicotinate"
is the most absorbable. Chromium polynicotinate is a unique molecule that binds chromium
with niacin, a compound found in breast milk, which helps the
body better absorb and process minerals.
In June of 2002, one form of chromium was affirmed by the FDA as "Generally Recognized
as Safe" (GRAS) for use in food products, one of only a handful of
ingredients to have secured this status at clinically effective doses
for use in foods marketed for weight loss and glucose control.
Vandium (vanadyl as an Amino Acid Chelate) is a trace element that exhibits a
variety of significant insulin-mimetic properties… doing
the job of insulin and transporting sugar to the cells.
Clinical trials indicate that "in vitro", vanadium salts have most of
the same major effects of insulin on insulin-sensitive tissues.
Favorable results are seen in animal models of insulin
deficiency, where vanadium significantly reduces blood glucose levels,
and in insulin-resistant diabetic animals, where vanadium improves glucose homeostasis.
In "in vivo" animal studies, examining the relationship between
hyperinsulinemia, insulin resistance and hypertension, vanadium
compounds produce significant, sustained decreases in both plasma
insulin concentration and blood pressure. Restoring plasma insulin
levels reversed the blood-pressure effect.
Clinical trials with vanadium compounds have produced benefits
in both Type I and Type II diabetic patients. Results have been better,
however, in Type II patients. Six Type II diabetic subjects treated with
100 milligrams of vanadyl sulfate daily for four weeks had significant
reductions in fasting plasma glucose; beneficial effects on insulin
sensitivity persisted for up to four weeks after vanadium treatment
ended.
Banaba Leaf
Banaba (Lagerstroemia speciosa) is a plant native to India, Southeast
Asia and the Philippines and has several medicinal uses. In many
cultures the banaba leaf is brewed into a tea and used as a treatment
for diabetes and as a weigh loss aid. Banaba Leaf Extract provides a
blood sugar lowering effect similar to that of insulin in that it
induces glucose transport from the blood into body cells.
Recently, researchers have isolated an active ingredient in the banaba
leaf called corosolic acid which was originally thought to be "the"
blood sugar regulating substance in the leaf. Other researchers have
found that corosolic acid may not be the only active ingredient in
banaba leaves. A study published in the journal Planta Medica in 2001
compared a whole-leaf extract of banaba with insulin in cell cultures.
The researchers concluded that the whole herb has a glucose lowering
effect. Another study reported that banaba leaf extract contains at
least three active ingredients that effect blood sugar.
In animal studies, administration of banaba leaf extract resulted in a
significant decrease of blood glucose. The same studies suggest that
corosolic acid may stimulate glucose transport into tissue. In other
animal studies, administration of banaba leaf extract resulted in
reduced weight gain, reduced triglyceride accumulation and reduced
adipose tissue, with no changes in diet. In noninsulin-dependent
animals, administration of banaba leaf extract resulted in suppressed
blood plasma glucose, lower serum insulin and lower urinary excretion
of glucose.
In clinical studies conducted by Dr William Judy and associates at the
Southeastern Institute of Biomedical Research in Bradenton, Florida, a
one per cent corosolic acid extract of banaba leaf reportedly reduced
serum glucose 20-30% in people with Type II diabetes, but did not reduce
serum glucose in healthy individuals.
In a prior study, some of the same researchers observed that
individuals receiving the corosolic acid extract had an increased
tendency toward weight loss… an average of about 3.2 pounds.
Gymnema Sylvestre
Gymnema Sylvestre is another herb, whose traditional use in treating
diabetes, has been backed up by recent medical research. Originating
from India, Gymnema Sylvestre is known as gur-mar, or "sugar
destroyer." When gymnema leaf is placed directly on the tongue, it
eliminates the sensation of sweetness, even if sugar is put in the
mouth immediately following. When taken internally, it helps to control
blood-sugar levels in diabetes.
The leaves of Gymnema sylvestre perform two significant functions
relative to diabetes. First, they suppress blood glucose, especially
after eating. Secondly, they are insulinotropic and promote insulin
secretion. By this two-pronged approach, Gymnema sylvestre proves a
valuable aid in diabetes control.
Scientists think its active ingredients (gymnemic acids) protect the
cells of the pancreas from free radical damage, so allowing them to
regenerate and produce insulin more effectively (Nutrition 2004; 20(3):
280-285). Studies have shown that gymnema can reduce glucose
absorption from the intestine, so helping to regulate blood sugar
levels. A recent Harvard study indicates the Gymnema lowers blood sugar
levels in Type I and Type II diabetics. At King's College in London,
study stated that Gymnema acts by increasing cell permatibility,
therefore reducing insulin resistance.
Fenugreek
Fenugreek (Trigonella foenum-graecum) is a tall annual herb that is
native to the Mediterranean, Ukraine, India and China. The plant bears
pods filled with numerous light brown, diamond-shaped seeds that
possess a sweet maple aroma and are commonly used in cookery and
flavouring. Studies reveal that fenugreek helps regulate blood glucose. The
glucose-regulating, antidiabetic properties of fenugreek seed are
linked to a novel free amino acid, 4-hydroxyisoleucine. This compound
stimulates insulin secretion, thereby limiting the extent to which
blood glucose is elevated; by promoting insulin secretion and
inhibiting the rise of blood glucose, it helps stabilise blood sugar
and reduces body fat production. In one human study, 15g/day fenugreek
significantly reduced glucose levels after meals. Today fenugreek shows
value as an antidiabetic agent with potential for weight control due to
its 4-hydroxyisoleucine content. Some supplements are capsules of
powdered seed, while others are more concentrated extracts standardized
to 4-hydroxyisoleucine.
Experimental and clinical studies have demonstrated the
antidiabetic properties of fenugreek seeds. The active ingredient
responsible for the antidiabetic properties of fenugreek is in the
defatted portion of the seed that contains the alkaloid trogonelline,
nicotinic acid and coumarin. Fenugreek contains six compounds that help
regulate blood sugar levels. Modern research shows that fenugreek seeds
not only lower blood glucose but reduce insulin levels, total
cholesterol and triglycerides, while increasing HDL (the good
cholesterol).
